SYNEPHRINE INJECTION 10MG 1ML
Brand: Atco Laboratories Limited
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Synephrine Im/Iv Specification
Requires Prescription (YES/NO)
Yes
Yes
Generics
Phenylephrine HCl
Phenylephrine HCl
Used For
Hypotension
Hypotension
How it works
Phenylephrine hydrochloride is a sympathomimetic agent with mainly direct effects on adrenergic receptors. It has predominantly alpha-adrenergic activity and is without significant stimulating effects on the central nervous system at usual doses. After injection it produces peripheral vasoconstriction and increased arterial pressure. It also causes reflex bradycardia.
Phenylephrine hydrochloride is a sympathomimetic agent with mainly direct effects on adrenergic receptors. It has predominantly alpha-adrenergic activity and is without significant stimulating effects on the central nervous system at usual doses. After injection it produces peripheral vasoconstriction and increased arterial pressure. It also causes reflex bradycardia.
Synephrine Im/Iv Usage And Safety
Dosage
Phenylephrine HCl
Phenylephrine HCl
Side Effects
Cardiac disorders: Bradycardia, AV block, ventricular extrasystoles, myocardial ischemia ; Gastrointestinal disorders: Nausea, vomiting ; General disorders and administrative site conditions: Chest pain, extravasation Immune system disorders: Sulfite sensitivity ; Nervous system disorders: Headache, nervousness, paresthesia, tremor ; Psychiatric disorders: Excitability Respiratory: Pulmonary edema, rales.
Cardiac disorders: Bradycardia, AV block, ventricular extrasystoles, myocardial ischemia ; Gastrointestinal disorders: Nausea, vomiting ; General disorders and administrative site conditions: Chest pain, extravasation Immune system disorders: Sulfite sensitivity ; Nervous system disorders: Headache, nervousness, paresthesia, tremor ; Psychiatric disorders: Excitability Respiratory: Pulmonary edema, rales.
Drug Interactions
• Monoamine oxidase inhibitors (MAOI), such as selegiline. • ß-adrenergic blockers • a-2 adrenergic agonists, such as clonidine • Steroids • Tricyclic antidepressants • Norepinephrine transport inhibitors, such as atomoxetine • Ergot alkaloids, such as methylergonovine maleate • Centrally-acting sympatholytic agents, such as guanfacine or reserpine • Atropine sulfate • Phenothiazines (e.g., chlorpromazine) and Amiodarone.
• Monoamine oxidase inhibitors (MAOI), such as selegiline. • ß-adrenergic blockers • a-2 adrenergic agonists, such as clonidine • Steroids • Tricyclic antidepressants • Norepinephrine transport inhibitors, such as atomoxetine • Ergot alkaloids, such as methylergonovine maleate • Centrally-acting sympatholytic agents, such as guanfacine or reserpine • Atropine sulfate • Phenothiazines (e.g., chlorpromazine) and Amiodarone.
Indication
It is indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation, in such settings as septic shock or anesthesia.
It is indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation, in such settings as septic shock or anesthesia.
When not to Use
The use of phenylephrine hydrochloride is contraindicated in patients with hypersensitivity to it or any of its components .
The use of phenylephrine hydrochloride is contraindicated in patients with hypersensitivity to it or any of its components .
Synephrine Im/Iv Precautions
Precaution
Because of its pressor effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
Because of its pressor effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.
Synephrine Im/Iv Warnings
Warning 1
Phenylephrine hydrochloride can cause severe bradycardia and decreased cardiac output.
Phenylephrine hydrochloride can cause severe bradycardia and decreased cardiac output.
Warning 2
The pressor response to adrenergic drugs, including phenylephrine, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.
The pressor response to adrenergic drugs, including phenylephrine, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.
Warning 3
Extravasation of phenylephrine can cause necrosis or sloughing of tissue.
Extravasation of phenylephrine can cause necrosis or sloughing of tissue.
Synephrine Im/Iv Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
Store this medicine at room temperature, away from direct light and heat.
