SEROXAT TABLETS 20MG
Brand: Glaxosmithkline Pakistan
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Seroxat Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Paroxetine HCl
Used For
Depression
How it works
The efficacy of paroxetine in the treatment of major depressive disorder, social anxiety disorder, obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD) is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin (5-hydroxy-tryptamine, 5-HT).
Seroxat Tablets Usage And Safety
Dosage
Paroxetine HCl
Side Effects
Abnormal bleeding, predominantly of the skin and mucous membranes (mostly ecchymosis), thrombocytopenia , allergic reactions (including urticaria and angioedema , syndrome of inappropriate anti-diuretic hormone secretion (SIADH) , hyponatraemia , somnolence, insomnia, agitation, abnormal dreams (including nightmares) , confusion, hallucinations , dizziness, tremor, headache.
Drug Interactions
L-tryptophan, triptans, tramadol, SSRIs, lithium, fentanyl and St. John’s Wort – Hypericum perforatum – preparations , Pimozide , carbamazepine, rifampicin, phenobarbital, phenytoin , Fosamprenavir , ritonavir , Procyclidine , carbamazepine, phenytoin, sodium valproate , tricyclic antidepressants, phenothiazine neuroleptics, risperidone, atomoxetine, certain Type 1c antiarrhythmics and metoprolol.
Indication
It is indicated for the symptomatic relief of Major Depressive Disorder.
When not to Use
Known hypersensitivity to paroxetine and excepients. Paroxetine should not be used in combination with monoamine oxidase (MAO) inhibitors (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor) or within 2 weeks of terminating treatment with MAO inhibitors. Likewise, MAO inhibitors should not be introduced within 2 weeks of cessation of therapy with paroxetine.
Seroxat Tablets Precautions
Precaution
Treatment with antidepressants is associated with an increased risk of suicidal thinking and behaviour in children and adolescents with Major Depressive Disorder (MDD) and other psychiatric disorders.
Seroxat Tablets Warnings
Warning 1
Epidemiological studies on bone fracture risk following exposure to some antidepressants, including SSRIs, have reported an association with fractures. The risk occurs during treatment and is greatest in the early stages of therapy. The possibility of fracture should be considered in the care of patients treated with paroxetine.
Warning 2
Caution is recommended in patients with severe renal impairment or in those with hepatic impairment.
Warning 3
Overall the incidence of seizures is less than 0.1% in patients treated with paroxetine. The drug should be discontinued in any patient who develops seizures.
Seroxat Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
