PIOZER PLUS TABLETS 15/850MG
Brand: Hilton Pharma
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Piozer Plus Specification
Requires Prescription (YES/NO)
Yes
Generics
Metformin HCl, Pioglitazone HCl
Used For
Diabetes
How it works
Pioglitazone: Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPAR?). It improves glycemic control by improving insulin sensitivity at key sites of insulin resistance namely adipose tissues, skeletal muscles and liver. Insulin resistance is known to play a major role in the pathogenesis of type 2 diabetes.Metformin HCl: Metformin HCI is an anti-hyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycemia.
Piozer Plus Usage And Safety
Dosage
Metformin HCl, Pioglitazone HCl
Side Effects
Combination therapy: Common: Anemia, visual disturbance, weight increased, arthralgia, headache, hematuria and erectile dysfunction. Uncommon: Flatulence.Individual active substances of the fixed dose combination: Pioglitazone: Common: Upper respiratory tract infection and hypoesthesia. Uncommon: Sinusitis and insomnia.Metformin HCl: Most common: Taste disturbance, nausea, vomiting, diarrhea, abdominal pain and loss of appetite. Uncommon: Decrease in Vitamin B12 absorption and serum levels and lactic acidosis.
Drug Interactions
Pioglitazone: An enzyme inhibitor of CYP2C8 (such as gemfibrozil and an enzyme inducer of CYP2C8 (such as rifampin) , Oral Contraceptives. Metformin HCI: Cationic drugs (e.g. , amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin , Furosemide , Nifedipine , diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytonin, nicotinic acid, sympathomimetics, calcium channel blocking drugs and isoniazid.
Indication
Pioglitazone + Metformin HCI is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus who are already treated with pioglitazone alone or who are not adequately controlled on metformin alone, or for those patients who have initially responded to pioglitazone alone and require additional glycemic control.
When not to Use
Pioglitazone + Metformin HCI is contraindicated in patients with:- Hypersensitivity to pioglitazone, metformin HCI or any component of the product.- Cardiac failure or history of cardiac failure (NYHA Class III or IV).- Hepatic impairment or evidence of active liver disease.- Acute or chronic disease which may cause tissue hypoxia such as cardiac or respiratory failure, recent myocardial infarction, shock.- Acute alcohol intoxication, alcoholism.- Renal failure or renal dysfunction (creatinine clearance <60mL/min), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction and septicemia.- Current bladder cancer or a history of bladder cancer.- Uninvestigated macroscopic haematuria.- Diabetic ketoacidosis or diabetic pre-coma.
Piozer Plus Precautions
Precaution
Pioglitazone exerts its anti-hyperglycemic effect only in the presence of insulin. Therefore, pioglitazone should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
Piozer Plus Warnings
Warning 1
Pioglitazone, like other thiazolidinediones, can cause fluid retention when used alone or in combination with other anti-diabetic agents, including insulin. Fluid retention may lead to or exacerbate heart failure. If these signs and symptoms develop, the heart failure should be managed according to current standards of care.
Warning 2
Therapy with pioglitazone, like other thiazolidinediones, may result in ovulation in some premenopausal anovulatory women. Thus, adequate contraception in premenopausal women should be recommended while taking Pioglitazone + Metformin HCI.
Warning 3
Patients receiving pioglitazone in combination with insulin or oral hypoglycemic agents may be at risk for hypoglycemia.
Piozer Plus Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
