ESTEZENE TABLETS 1MG
Brand: Adamjee Pharmaceuticals
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Estezene Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Trifluoperazine HCl
Used For
Schizophrenia
How it works
A piperazine, phenothiazine tranquiliser with potent anti-psychotic, anxiolytic and antiemetic activity, and a pharmacological profile of moderate sedative and hypotensive properties and fairly pronounced tendency to cause extra pyramidal reactions.
Estezene Tablets Usage And Safety
Dosage
Trifluoperazine HCl
Side Effects
Leucopenia , thrombocytopenia , hyperprolactinaemia , acute dystonias and dyskinesias , Parkinsonism , drowsiness , insomnia , tachycardia , hypotension , erythemas , anticholinergic effects , anorexia , depression , rash , photosensitivity , convulsions , blood dyscrasias , extrapyramidal symptoms , agitation , mental dulness , dizziness , ECG changes . Rarely , agranulocytosis , jaundice , neuroleptic malignant syndrome .
Drug Interactions
• Strong pain killers (e.g. codeine) • Medicines which result in lowering of blood pressure (e.g. guanethidine) • Anticholinergic medicines used to reduce saliva and lung secretions (e.g. atropine, procyclidine)• Antidepressants (e.g. other phenothiazines, lithium) • Medicines for fits (anticonvulsants) • Medicines for Parkinson’s disease (e.g. levodopa) • Blood thinning medicines (anticoagulants such as warfarin) •Medicines used to treat iron poisoning (desferrioxamine) • Antacids used to treat indigestion • Medicines for psychiatric conditions (neuroleptics) • Heart medicines which prolong the QT interval (e.g quinidine, disopyramide, procainamide, amiodarone, sotalol) • Drugs causing electrolyte imbalances (e.g diuretics) .
Indication
• At a low dose, it is used to manage anxiety and depression. It is used in this way for short periods of time . • It may also be used to treat nausea (feeling sick) and vomiting (being sick).• At high doses, it is used to treat and prevent relapses of schizophrenia (a serious mental illness) and related conditions.
When not to Use
• If you are allergic to trifluoperazine hydrochloride or any of the other ingredients of this medicine . •If you are suffering from liver problems, blood disorders, inability of the heart to maintain adequate circulation causing breathlessness and swelling of the ankles. You should not be given this medicine if you are in a coma, especially if you have taken other central nervous system depressants .
Estezene Tablets Precautions
Precaution
Cases of venous thromboembolism (VTE) have been reported with antipsychotic drugs. Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with Trifluoperazine and preventive measures undertaken .
Estezene Tablets Warnings
Warning 1
Trifluoperazine should be discontinued as the first sign of clinical symptoms of tardive dyskinesia and Neuroleptic Malignant Syndrome.
Warning 2
In patients with Parkinson's disease, symptoms may be worsened, and the effects of levodopa reversed. Since phenothiazines may lower the convulsive threshold, patients with epilepsy should be treated with caution, and metrizamide avoided. Although 'Trifluoperazine' has minimal anticholinergic activity, this should be borne in mind when treating patients with narrow angle glaucoma, myasthenia gravis or prostatic hypertrophy.
Warning 3
Acute withdrawal symptoms including nausea, vomiting and insomnia have been described after abrupt cessation of high doses of antipsychotic drugs.
Estezene Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
